Dynamins at a glance.

نویسندگان

Jürgen A W Heymann

Jenny E Hinshaw

چکیده

The superfamily of dynamins includes classical dynamins and dynamin-related proteins. Classical dynamins are proteins that share sequence similarity with the first described dynamin, which is a large GTPase with five characteristic domains. Dynamin-related proteins differ from classical dynamins in that they contain, at a minimum, three of the five characteristic domains. Dynamins are associated with diverse cellular processes, including the release of transport vesicles [as in clathrin-mediated endocytosis (CME)], fusion and fission of mitochondria, division of chloroplasts and peroxisomes, cell division, and resistance to viral infections. Corresponding with their roles in a broad range of cellular functions, dynamins are found in all eukaryotic phyla (panel 3a in the poster). In this article and its accompanying poster, we present selected aspects of what is known about individual members of this superfamily in the context of their structure, function, interaction partners and roles in diseases.

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